|Year : 2023 | Volume
| Issue : 2 | Page : 638
Bilateral proliferative retinopathy with blood-tinged hypopyon as the first manifestation of chronic myeloid leukemia
Uveitis and Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India
|Date of Web Publication||28-Apr-2023|
Uveitis and Cornea Services, Medical Research Foundation, Sankara Nethralaya, 18, College Road, Chennai - 600 006, Tamil Nadu
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Agarwal M. Bilateral proliferative retinopathy with blood-tinged hypopyon as the first manifestation of chronic myeloid leukemia. Indian J Ophthalmol Case Rep 2023;3:638
|How to cite this URL:|
Agarwal M. Bilateral proliferative retinopathy with blood-tinged hypopyon as the first manifestation of chronic myeloid leukemia. Indian J Ophthalmol Case Rep [serial online] 2023 [cited 2023 Jun 5];3:638. Available from: https://www.ijoreports.in/text.asp?2023/3/2/638/374900
A 36-year-old healthy man presented with bilateral decreased vision and eye pain for 2 weeks. Fundus examination showed vitreous hemorrhage and neovascular frond (OD) [Figure 1]a and tortuous retinal vessels, retinal hemorrhages, neovascularization, cotton wool spots, and vitreous hemorrhage (OS) [Figure 1]b., Slit-lamp examination showed anterior uveitis with rubeosis iridis and blood-tinged hypopyon (OD) [Figure 1]c, [Figure 1]d and white hypopyon (OS) [Figure 1]e. Peripheral blood smear showed hyperleukocytosis with myeloid left shift, thrombocytosis, 16% metamyelocytes, and 3% myeloblasts. Cytogenetic analysis was positive for the Philadelphia chromosome in all metaphase cells. Bone marrow aspiration cytology revealed hypercellular bone marrow with features consistent with chronic myeloid leukemia.
|Figure 1: Fundus montage of the right eye (a) showing vitreous haze with neovascular frond, and the left eye (b) showing tortuous retinal vessels with retinal hemorrhages and neovascularization. Slit-lamp photograph of the right eye showing blood-tinged hypopyon with rubeosis iridis (c, d) and the left eye with white hypopyon (e)|
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| References|| |
Yassin MA, Ata F, Mohamed SF, Alkhateeb A, Naeem U, Al-Qatami AI, Nashwan AJ, Fernyhough LJ. Ophthalmologic manifestations as the initial presentation of chronic myeloid leukemia: A review. Surv Ophthalmol 2022;67:530-43.
Huynh TH, Johnson MW, Hackel RE. Bilateral proliferative retinopathy in chronic myelogenous leukemia. Retina 2007;27:124-5.
Tyagi M, Govindhari V, Pappuru RR, Ambiya V. Bilateral hypopyon uveitis in chronic myeloid leukemia. Ocul Oncol Pathol 2017;4:12-5.