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OPHTHALMIC IMAGE
Year : 2023  |  Volume : 3  |  Issue : 1  |  Page : 247

Mizuo–Nakamura phenomenon in a 10-year-old boy with Oguchi disease


1 Department of Vitreo-Retina, Trilochan Netralaya, Sambalpur, Odisha, India
2 Department of Cataract and IOL, Trilochan Netralaya, Sambalpur, Odisha, India
3 Department of Optometry, Trilochan Netralaya, Sambalpur, Odisha, India
4 Department of Orbit and Oculoplasty, Trilochan Netralaya, Sambalpur, Odisha, India

Date of Web Publication20-Jan-2023

Correspondence Address:
Chitaranjan Mishra
Department of Vitreo-Retinal Services, Trilochan Netralaya, Sambalpur - 768 004, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_1675_22

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How to cite this article:
Mishra C, Dash A, Sahoo SN, Sahoo JK, Sah BP, Bhattacharjee R, Sharma A, Sahoo SP. Mizuo–Nakamura phenomenon in a 10-year-old boy with Oguchi disease. Indian J Ophthalmol Case Rep 2023;3:247

How to cite this URL:
Mishra C, Dash A, Sahoo SN, Sahoo JK, Sah BP, Bhattacharjee R, Sharma A, Sahoo SP. Mizuo–Nakamura phenomenon in a 10-year-old boy with Oguchi disease. Indian J Ophthalmol Case Rep [serial online] 2023 [cited 2023 Feb 1];3:247. Available from: https://www.ijoreports.in/text.asp?2023/3/1/247/368157



A 10-year-old boy presented with defective vision in the dark since childhood. His vision was 20/20 OU. Fundus examination revealed a golden yellow appearance [Figure 1]a and [Figure 1]b, which disappeared after 4 hours of dark adaptation [Figure 1]c and [Figure 1]d. There were no bony spicules and the macula was normal. He was diagnosed with Oguchi disease with Mizuo–Nakamura phenomenon OU.[1],[2] He was counseled regarding the guarded visual prognosis and was explained the need for family screening. The diagnosis of Oguchi disease is clinical and is based on the history of night blindness and identification of the Mizuo–Nakamura phenomenon in the fundus.
Figure 1: (a and b) Fundus photos OU showing golden yellow reflex suggestive of Oguchi disease. (c and d) Fundus photos OU showing the Mizuo–Nakamura phenomenon, that is, the disappearance of the golden yellow reflex and the look of a normal retina

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Yamamoto S, Hayashi M, Takeuchi S, Shirao Y, Kita K, Kawasaki K. Normal S cone electroretinogram b-wave in Oguchi's disease. Br J Ophthalmol 1997;81:1043-5.  Back to cited text no. 1
    
2.
Sergouniotis PI, Davidson AE, Sehmi K, Webster AR, Robson AG, Moore AT. Mizuo-Nakamura phenomenon in Oguchi disease due to a homozygous nonsense mutation in the SAG gene. Eye 2011;25:1098-101.  Back to cited text no. 2
    


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