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Year : 2023  |  Volume : 3  |  Issue : 1  |  Page : 118-120

Bilateral optic neuritis as a presentation of myelin oligodendrocyte glycoprotein antibody associated disease in a child

Department of Pediatric Ophthalmology and Strabismology, Sankara Eye Hospital, Coimbatore, Tamil Nadu, India

Correspondence Address:
Sai Lakshmi Raghavan
Department of Pediatric Ophthalmology and Strabismology, Sankara Eye Hospital, Coimbatore - 641 035, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1803_22

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Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), although rare, is now recognized as a distinct demyelinating disorder. The entity differs from multiple sclerosis and neuromyelitis optica spectrum disorder in terms of clinical presentation, radiodiagnostic features, and prognosis. Here, we present a 5-year-old female who presented with bilateral, painless loss of vision since 3 days. There was optic nerve enhancement, but no brain parenchymal lesions. She tested negative for Aquaporin-4 antibodies, and CSF analysis showed no oligoclonal bands. Serum analysis revealed positivity for myelin oligodendrocyte antibodies. There was full visual recovery on treatment with systemic steroids. The report highlights the need for testing for MOG–IgG antibodies, especially in children with bilateral optic neuritis. It is essential to differentiate the entity from other demyelinating conditions. The prognosis is usually benign.

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