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Year : 2022  |  Volume : 2  |  Issue : 3  |  Page : 722-724

Tamoxifen maculopathy mimicking type-2 macular telangiectasia (MacTel-2)

Department of Vitreoretinal Services, Giridhar Eye Institute, Cochin, Kerala, India

Correspondence Address:
Dr. Anantharaman Giridhar
Department of Vitreoretinal Services, Giridhar Eye Institute, Cochin, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_459_22

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Tamoxifen citrate is an antiestrogen agent used in the treatment of breast carcinoma. Incidence of ocular toxicity, in the range of 0.9–-11%, has been reported following its use. Since the clinical picture, especially crystals and cavitation, seen in tamoxifen maculopathy resembles type-2 macular telangiectasia (MacTel-2), differentiating them requires detailed multimodal imaging. We present a rare case of tamoxifen maculopathy mimicking MacTel-2 in an Indian patient. A 55-year-old female with a history of breast carcinoma had been taking tamoxifen 20 mg once daily (cumulative dose of 57.6 g) for 8 years. Color fundus photo showed crystals in foveal and parafoveal region. Further multimodal imaging with confocal blue reflectance, spectral domain optical coherence tomography, fundus autofluorescence, and OCT-angiography demonstrated close resemblance to MacTel-2 features. Thus, it is important to elicit a detailed history in female patients with a history of breast carcinoma and seek oncology consultation once tamoxifen toxicity is seen.

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