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CASE REPORT
Year : 2022  |  Volume : 2  |  Issue : 2  |  Page : 517-519

Internuclear ophthalmoplegia as a result of cerebral metastatic disease: Workup, pathophysiology, and clinical pearls


1 Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, United States
2 Department of Graduate Medical Education, Kendall Regional Medical Center, Kendall, FL, United States

Correspondence Address:
Divy Mehra
92 SW 3rd St #505, Miami, FL 33130
United States
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_1893_21

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This case demonstrates an acute case of internuclear ophthalmoplegia (INO) caused by cerebral metastasis from a small cell lung cancer, the only such case documented in the literature. A 54-year-old male presented to the emergency department for worsening headache and diplopia, secondary to INO. On further examination, a CT scan of the chest revealed a 6.1 × 4.8 × 6.8 cm solid mass in the right lower lung consistent with small-cell lung cancer. T2-weighted MRI exhibited bilateral supratentorial and infratentorial lesions interpreted as metastatic cancer. The patient's symptoms, including INO, were caused by the mass effect from the metastatic brain lesions.


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