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Year : 2022  |  Volume : 2  |  Issue : 2  |  Page : 463-464

Tamoxifen maculopathy – A case with early optical coherence tomography changes

Pushpagiri Eye Institute, Department of Vitreo-Retinal Services, Secunderabad, Telangana, India

Correspondence Address:
P Sai Kiranmayee
302, Vasavi Bhuvana Apartment, Srinagar Colony, Hyderabad - 500 073, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_2350_21

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Tamoxifen is an antiestrogen agent used as adjuvant therapy in breast carcinoma. Crystalline maculopathy due to tamoxifen toxicity, though rare, causes irreversible changes in the retina. High-resolution imaging like spectral-domain optical coherence tomography (SD-OCT) can detect early degenerating changes like crystalline deposits and cavitation in the retina. Early detection helps in the prevention of visual loss by prompt consideration in discontinuing or replacing the drug. Periodic screening with SD-OCT is essential as structural changes in the retina are noted even in asymptomatic patients receiving low-dose tamoxifen.

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