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Year : 2021  |  Volume : 1  |  Issue : 4  |  Page : 619-621

Keratitis–ichthyosis–deafness (KID) syndrome: Ocular manifestations and management

1 Department of Ophthalmology, Torrecárdenas University Hospital, Almería, Spain
2 Departament of Nursing, Physiotherapy and Medicine, University of Almería, Almería, Spain

Correspondence Address:
Dr. Antonio Perez-Rueda
Department of Ophthalmology, Torrecardenas University Hospital, Almeria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_3703_20

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Keratitis–ichthyosis–deafness (KID) syndrome is a rare hereditary disorder caused by the gene GJB2 encoding connexin 26. Patients present the characteristic clinical triad of congenital bilateral sensorineural hearing loss, keratitis, and ichthyosis. Ocular manifestations are corneal neovascularization and severe Meibomian dysfunction associated with hyperkeratotic lid border. Treatments with ocular lubricants, autologous serum, tetracycline, and anti-inflammatory agents have been described. New therapies such as retinoids, gas-permeable contact lenses, or antiangiogenic agents may be indicated. However, sometimes surgical options such as keratoplasty and keratoprosthesis are needed. We report two cases of KID syndrome with different ocular manifestations and management.

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