• Users Online: 343
  • Print this page
  • Email this page
CASE REPORT
Year : 2021  |  Volume : 1  |  Issue : 3  |  Page : 608-610

Acute orbital presentation in an activated B-cell subtype, diffuse large B-cell lymphoma: clinicoradiological, histopathological and immunohistochemical correlation


1 Ophthalmic Plastics, Orbit and Ocular Oncology Services, LV Prasad Eye Institute, MTC Campus, Patia, Bhubaneswar, Odisha; Operation Eyesight Universal Institute for Eye Cancer, Hyderabad, Telengana, India
2 Kanupriya Dalmia Ocular Pathology Laboratory, LV Prasad Eye Institute, MTC Campus; Department of Pathology, Kalinga Institute of Medical Sciences, Patia, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. Ruchi Mittal
Consultant Pathologist, Kanupriya Dalmia Ocular Pathology Laboratory, LV Prasad Eye Institute, MTC Campus and Professor, Department of Pathology, Kalinga Institute of Medical Sciences, Patia, Bhubaneswar - 751 024, Odisha
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_2773_20

Rights and Permissions

Non-Hodgkin's lymphoma is the most common ocular adnexal neoplasm in adults. Involvement of the ocular adnexae can be primary in origin or secondary resulting from systemic disease. We report a 66-year-old male patient with an acute onset of orbital lymphoma with several atypical clinicoradiological features in the absence of any clinical signs of systemic disease at presentation. A histopathological diagnosis of diffuse large B-cell lymphoma was made and immunophenotyping revealed it to be an activated B-cell (ABC) subtype with a “non-double-expressor” phenotype. Rapid progression of disease was noted and resulted in a poor outcome. Clinicoradiological, histopathological, and immunohistochemical correlation is critical for accurate diagnosis in such situations. Additional immunophenotyping to delineate the subtype of DLBCL may have an important role in decision-making regarding the choice of treatment, and may contribute to the prognostication of disease outcome.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed106    
    Printed0    
    Emailed0    
    PDF Downloaded20    
    Comments [Add]    

Recommend this journal