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Year : 2021  |  Volume : 1  |  Issue : 3  |  Page : 476-478

Medical device composed of amniotic membrane inhibits the rapid progression of acute calcareous degeneration caused by ocular graft-versus-host disease: Case report

1 Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
2 Department of Ophthalmology, National Taiwan University Hospital; Advanced Ocular Surface and Corneal Nerve Regeneration Center, National Taiwan University Hospital; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan

Correspondence Address:
Dr. Wei-Li Chen
Department of Ophthalmology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_2540_20

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A 27-year-old man who underwent hematopoietic stem cell transplantation (HSCT) for the treatment of T-cell acute lymphoblastic leukemia presented with bilateral persistent corneal erosions. Acute calcareous deposition was later found in both eyes, and the ocular condition deteriorated rapidly. Active treatment with topical lubricants, topical anti-inflammatory agents, autologous serum, and punctal plug insertion were applied but in vain. Amniotic membrane (Prokera) was then applied in both eyes, and the corneal erosion and ocular inflammation improved rapidly. The intrastromal calcium deposition remained and did not progress.

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