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 Table of Contents  
OPHTHALMIC IMAGE
Year : 2021  |  Volume : 1  |  Issue : 3  |  Page : 462

Blue autofluorescence markers of reactivation of choroidal neovascularization in age-related macular degeneration


1 Kamalnayan Bajaj Sankara Nethralaya, Kolkata, West Bengal, India
2 Department of Retina Services, B. B. Eye Foundation, Kolkata, West Bengal, India

Date of Web Publication02-Jul-2021

Correspondence Address:
Dr. Kumar Saurabh
Kamalnayan Bajaj Sankara Nethralaya, DJ16, Action Area 1D, Newtown, Kolkata - 700 156, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_3101_20

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How to cite this article:
Herekar S, Roy R, Saurabh K. Blue autofluorescence markers of reactivation of choroidal neovascularization in age-related macular degeneration. Indian J Ophthalmol Case Rep 2021;1:462

How to cite this URL:
Herekar S, Roy R, Saurabh K. Blue autofluorescence markers of reactivation of choroidal neovascularization in age-related macular degeneration. Indian J Ophthalmol Case Rep [serial online] 2021 [cited 2021 Jul 26];1:462. Available from: https://www.ijoreports.in/text.asp?2021/1/3/462/320104



Spectral-domain optical coherence tomography (SDOCT) image of scarred type 1 choroidal neovascularisation (CNV) showed degenerative intraretinal cysts and flattening hyperreflective double-layer sign [Figure 1]a. Blue autofluorescence (BAF) showed central hypoautofluorescence surrounded by rim of hyperautofluorescence [Figure 1]b. Four months later there was increased intraretinal edema and subretinal fluid (SRF) at the nasal edge suggestive of activity [Figure 1]c. BAF showed nasal extension of hypoautofluorescence due to blockage by retinal thickening. Surrounding hyperautofluorescent rim also extended nasally which may be due to proliferation of retinal pigment epithelium around CNV [Figure 1]d.[1],[2] BAF corroborated the reactivation of CNV noted on SDOCT.
Figure 1: (a) Spectral domain optical coherence tomography (SDOCT) line scan through the fovea shows box shaped cysts with straight walls in the inner nuclear layer (red arrow) suggestive of degenerative cysts. There is vitreomacular traction. Flattening hyperreflective double layer sign (DLS) is noted (blank yellow arrow).(b) Blue autofluorescence (BAF) image of the right eye shows heterogenous hypoautofluorescence at the center of macula (blank red star) due to damage to retinal pigment epithelium (RPE) in a sub-RPE Type 1 choroidal neovascularisation (CNV). Rim of hyperautofluorescence (yellow arrow) is seen around the scarred CNV. (c) SDOCT line scan through the fovea shows increased intraretinal cysts (red arrow) with increase in the nasal extent of DLS and nasal subretinal fluid (SRF) (yellow arrow) suggestive of reactivation of CNV. (d) BAF image shows extension of hypoautofluorescence to hitherto normal nasal areas (blank red star) due to the masking effect of thickened retina. Rim of hyperautofluorescence (yellow arrow) also extends around this new area of nasal hypoautofluorescence possibly caused by RPE proliferation at the margin of CNV

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Acknowledgements

Nil.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
McBain VA, Townend J, Lois N. Fundus autofluorescence in exudative age-related macular degeneration. Br J Ophthalmol 2007;91:491-6.  Back to cited text no. 1
    
2.
Dandekar SS, Jenkins SA, Peto T, Scholl HP, Sehmi KS, Fitzke FW, et al. Autofluorescence imaging of choroidal neovascularization due to age-related macular degeneration. Arch Ophthalmol 2005;123:1507-13.  Back to cited text no. 2
    


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