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Year : 2021  |  Volume : 1  |  Issue : 3  |  Page : 458

Capsular neovascularisation in uveitis

Department of Ophthalmology, Sri Sankaradeva Nethralaya, Guwahati, Assam, India

Date of Web Publication02-Jul-2021

Correspondence Address:
Dr. Suklengmung Buragohain
DNB Resident, Sri Sankaradeva Nethralaya, 96 Basistha Road, Guwahati - 781 028, Assam
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_3625_20

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How to cite this article:
Bhattacharjee H, Buragohain S, Javeri H. Capsular neovascularisation in uveitis. Indian J Ophthalmol Case Rep 2021;1:458

How to cite this URL:
Bhattacharjee H, Buragohain S, Javeri H. Capsular neovascularisation in uveitis. Indian J Ophthalmol Case Rep [serial online] 2021 [cited 2021 Jul 26];1:458. Available from: https://www.ijoreports.in/text.asp?2021/1/3/458/320081

A 30-year-old woman with a history of posterior uveitis (toxoplasma) presented with diminished vision (counting fingers) since 1 year. Examination revealed a quiet anterior chamber with posterior synechiae over a cataractous lens and fine arborizing vascular growth over the anterior lens capsule [Figure 1]. On ultrasonography B-scan, inferior retinal traction was noted. The patient was started on eye drop nepafenac 0.1% and was kept on follow-up.
Figure 1: Slit-lamp photograph with direct focal and retro-illumination showing posterior synechiae (white arrowhead) with few areas of fibrous growth (yellow arrowhead), some pigments over the anterior lens capsule, capsular folds (white star) and fine arborizing vessels (yellow arrow) over the anterior lens capsule of a cataractous lens

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Inflammation and ischemia result in the expression and transportation of vascular endothelial growth factor (VEGF) to the anterior chamber with the help of nuclear factor-kβ (NF-kβ) resulting in neovascularisation of the lens capsule.[1],[2],[3],[4] Use of anti-VEGF drugs either by intravitreal or intracameral route maybe of benefit in resolving the condition.[5]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 2000;60:5334e9.  Back to cited text no. 1
Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331:1480-7.  Back to cited text no. 2
Gupta S, Gogia V, Ramya A, Sihota R. Capsular neovascularisation: Case report and review of literature. Eye 2014;28:358-9.  Back to cited text no. 3
Walkden A, Tan SZ, Au L, Mercieca K. Vascularisation of the anterior lens capsule in an eye with excellent visual acuity. BMJ Case Rep 2017;2017:bcr-2017-220163.  Back to cited text no. 4
Tai F, Mandelcorn ED, Somani S. Posterior lens capsule neovascularization treated with anti-VEGF complicated by phacogenic uveitis. Am J Ophthalmol Case Rep 2020;20:100943.  Back to cited text no. 5


  [Figure 1]


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