|Year : 2021 | Volume
| Issue : 3 | Page : 414-415
Unilateral incomplete retinal vascularization due to congenital heart disease in a full-term newborn
Franco Benvenuto, Luis Diaz Gonzalez, María Celeste Mansilla, Adriana Fandiño
Ophthalmology Service, SAMIC Pediatric Hospital, Buenos Aires, Argentina
|Date of Submission||27-Sep-2020|
|Date of Acceptance||22-Feb-2021|
|Date of Web Publication||02-Jul-2021|
Dr. Franco Benvenuto
Ophthalmology Service at Hospital Nacional de Pediatria Prof. Dr. Juan P. Garrahan, Buenos Aires
Source of Support: None, Conflict of Interest: None
Keywords: Pediatric retina, retina, ROP
|How to cite this article:|
Benvenuto F, Diaz Gonzalez L, Mansilla MC, Fandiño A. Unilateral incomplete retinal vascularization due to congenital heart disease in a full-term newborn. Indian J Ophthalmol Case Rep 2021;1:414-5
|How to cite this URL:|
Benvenuto F, Diaz Gonzalez L, Mansilla MC, Fandiño A. Unilateral incomplete retinal vascularization due to congenital heart disease in a full-term newborn. Indian J Ophthalmol Case Rep [serial online] 2021 [cited 2021 Jul 26];1:414-5. Available from: https://www.ijoreports.in/text.asp?2021/1/3/414/320102
A 6-day-old full-term baby girl was hospitalized in the intensive care unit and had a history of tetralogy of Fallot (TOF), diaphragmatic hernia, and polydactyly in one of her hands. The external eye examination was normal. The fundus examination of the right eye (OD) was difficult due to poor pupillary dilation. Macular edema, preretinal hemorrhages, vascular tortuosity, arteriovenous shunts, and avascular retina were observed [Figure 1]a. The left eye fundus was normal [Figure 1]b.
The condition was interpreted as ischemic retinopathy with vascular thrombotic cause related to the cardiological congenital disease and retinal vascularization interruption. Laboratory tests for congenital infectious diseases and molecular genetic testing were negative.
|Figure 1: (a) Right eye fundus photograph at initial exam showing retinal hemorrhages, macular edema, arteriovenous shunts, and avascular peripheric retina. (b) Left eye fundus with normal retinal vasculature|
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It was decided to perform treatment with intravitreous bevacizumab 0.625 mg in 0.025 mL. One week after the injection, pupillary dilation improved, the vitreous became clearer, there were fewer hemorrhages and vascular tortuosity. An extensive retinal without vessels was seen [Figure 2].
|Figure 2: Right eye fundus photograph 1 week after intravitreal bevacizumab injection, showing improvement of the macular edema and retinal hemorrhages. An extensive avascular retina can be seen|
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| Discussion|| |
Retinal vascular dysgenesis can occasionally occur in full-term infants. The risk factors for the development of such retinopathy changes in full-term newborns are oxygen administration, low-birth weight, multiple births, hypoxia, or sepsis. Some of them are considered Retinopathy of Prematurity-Like retinopathies.
Cyanotic heart disease, such as tetralogy of Fallot (TOF), is known to cause retinal vascular tortuosity, retinal hemorrhages, retinal venous occlusions, and macular edema., However, it is unlikely to find retina vascularization interrupted.
There are a few reports of retinal arteriovenous anastomosis in conjunction with congenital cytomegalovirus (CMV) infection. Nevertheless, our patient was negative for CMV and other congenital infections.
To our knowledge, there are no previous reports of retinal vascularization interruption due to a complication of congenital heart disease in a newborn. A prompt screening of neonates and early treatment should prevent visual impairment in these cases.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
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[Figure 1], [Figure 2]