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 Table of Contents  
Year : 2021  |  Volume : 1  |  Issue : 2  |  Page : 175

Complete regression of primary iris lymphoma following systemic chemotherapy

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA

Date of Web Publication01-Apr-2021

Correspondence Address:
Dr. Carol L Shields
Ocular Oncology Service, 840 Walnut Street, Suite 1440, Philadelphia - 19107, PA
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_2616_20

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How to cite this article:
Taylor OS, Dockery PW, Dunn JP, Shields CL. Complete regression of primary iris lymphoma following systemic chemotherapy. Indian J Ophthalmol Case Rep 2021;1:175

How to cite this URL:
Taylor OS, Dockery PW, Dunn JP, Shields CL. Complete regression of primary iris lymphoma following systemic chemotherapy. Indian J Ophthalmol Case Rep [serial online] 2021 [cited 2021 Jul 29];1:175. Available from: https://www.ijoreports.in/text.asp?2021/1/2/175/312387

A 64-year-old female with recent-onset unilateral ocular hypertension and suspected anterior uveitis OS was treated with anti-glaucoma and corticosteroid eyedrops without benefit. Upon referral, visual acuity was 20/50. Heterochromia was noted. The iris was markedly thickened; there was corectopia, iris neovascularization, anterior chamber cellularity, and keratic precipitates [Figure 1]a. Anterior segment optical coherence tomography (AS-OCT) revealed solid iris infiltration filling the anterior chamber [[Figure 1]b, arrows]. There were no posterior segment or systemic abnormalities. Fine needle aspiration biopsy confirmed large B-cell lymphoma.[1] Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone (R-CHOP) (3 infusions), and high-dose methotrexate (2 infusions) induced complete tumor regression within 2 months [Figure 1]c, confirmed on AS-OCT [[Figure 1]d, arrowheads].
Figure 1: At presentation, there was a diffuse salmon-colored iris infiltrate with neovascularization and associated keratic precipitates (a). Anterior segment optical coherence tomography (AS-OCT) demonstrated a thick iris infiltrate with irido-corneal touch (b). After treatment, the infiltrate had completely regressed, resulting in resolution of the tumor and posterior synechiae (c). After treatment, AS-OCT revealed a flat iris with no infiltrate (d)

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Support provided in part by the Eye Tumor Research Foundation, Philadelphia, PA (CLS).

Conflicts of interest

There are no conflicts of interest.

  References Top

Mashayekhi A, Shields CL, Shields JA. Iris involvement by lymphoma: A review of 13 cases. Clin Experiment Ophthalmol 2013;41:19-26.  Back to cited text no. 1


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